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CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.
HMG
Also known as: Human Menopausal Gonadotropin, Menotropin, Menopur, Repronex
Human Menopausal Gonadotropin is a purified preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity, originally extracted from postmenopausal urine. It is used for fertility treatment and is considered superior to HCG alone for restoring spermatogenesis after prolonged androgen suppression.
Risk Level
Medium RiskDifficulty
Advanced| CAS Number | 9002-68-0 |
| Class | Hormone |
| Category | SERMs & AIs |
Mechanism of Action
HMG provides both FSH and LH activity, directly stimulating both Sertoli cells (via FSH) for spermatogenesis and Leydig cells (via LH) for testosterone production. The FSH component is critical for initiating and maintaining sperm production, which HCG alone cannot fully support. This dual-action makes HMG particularly valuable for restoring fertility in men with gonadotropin deficiency or after prolonged steroid-induced suppression.
Dosing Research
Male fertility: 75-150 IU intramuscularly or subcutaneously 3 times per week, often combined with HCG. Female fertility (controlled ovarian stimulation): 75-450 IU/day. Treatment duration varies from weeks to months depending on response. Requires monitoring with blood work and, for females, ultrasound.
Side Effects & Risks
Injection site pain and swelling. Gynecomastia due to stimulated estrogen production. Headache and fatigue. Ovarian hyperstimulation syndrome (females). Expensive compared to HCG. Multiple pregnancy risk in assisted reproduction. Less commonly used in PCT due to cost and complexity.
Research Studies
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Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.