Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.
Anastrozole
Also known as: Arimidex, Adex
Anastrozole is a potent, selective non-steroidal aromatase inhibitor that reduces estradiol levels by approximately 80-85%. It is widely used in breast cancer treatment and is the most commonly employed AI during anabolic steroid cycles to manage estrogen-related side effects.
Risk Level
Medium RiskDifficulty
Intermediate| CAS Number | 120511-73-1 |
| Molecular Formula | C17H19N5 |
| Class | Other |
| Category | SERMs & AIs |
Mechanism of Action
Anastrozole reversibly binds to the aromatase enzyme (CYP19A1), competitively inhibiting the conversion of androgens to estrogens. This reduces circulating estradiol levels significantly within 24 hours of dosing. As a non-steroidal, reversible inhibitor, estrogen levels recover relatively quickly after discontinuation, allowing for dose adjustment flexibility.
Dosing Research
Breast cancer: 1 mg/day orally. On-cycle estrogen management: 0.25-0.5 mg every other day, titrated based on estradiol blood work. Half-life is approximately 40-50 hours, supporting every-other-day dosing. Steady state reached in about 7 days.
Side Effects & Risks
Joint pain and stiffness are the most common complaints. Bone mineral density loss with prolonged use. Lipid profile worsening (reduced HDL, elevated LDL). Fatigue, headache, and hot flashes. Over-suppression of estradiol can cause mood disturbances, sexual dysfunction, and impaired recovery.
Research Studies
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Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.