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CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

OtherIntermediateMedium Risk

Anastrozole

Also known as: Arimidex, Adex

Anastrozole is a potent, selective non-steroidal aromatase inhibitor that reduces estradiol levels by approximately 80-85%. It is widely used in breast cancer treatment and is the most commonly employed AI during anabolic steroid cycles to manage estrogen-related side effects.

Evidence85/100 — Strong

Risk Level

Medium Risk

Difficulty

Intermediate
CAS Number120511-73-1
Molecular FormulaC17H19N5
ClassOther
CategorySERMs & AIs

Mechanism of Action

Anastrozole reversibly binds to the aromatase enzyme (CYP19A1), competitively inhibiting the conversion of androgens to estrogens. This reduces circulating estradiol levels significantly within 24 hours of dosing. As a non-steroidal, reversible inhibitor, estrogen levels recover relatively quickly after discontinuation, allowing for dose adjustment flexibility.

Dosing Research

Breast cancer: 1 mg/day orally. On-cycle estrogen management: 0.25-0.5 mg every other day, titrated based on estradiol blood work. Half-life is approximately 40-50 hours, supporting every-other-day dosing. Steady state reached in about 7 days.

Side Effects & Risks

Joint pain and stiffness are the most common complaints. Bone mineral density loss with prolonged use. Lipid profile worsening (reduced HDL, elevated LDL). Fatigue, headache, and hot flashes. Over-suppression of estradiol can cause mood disturbances, sexual dysfunction, and impaired recovery.

Research Studies

Disclaimer

CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

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