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OtherAdvancedLow Risk

Coluracetam

Also known as: MKC-231, BCI-540

Coluracetam is a fat-soluble racetam originally developed by Mitsubishi Tanabe Pharma for Alzheimer's disease. It is unique among racetams for its potent enhancement of high-affinity choline uptake (HACU), and users frequently report vivid color vision enhancement as a distinctive subjective effect.

Evidence25/100 — Emerging

Risk Level

Low Risk

Difficulty

Advanced
CAS Number135463-81-9
Molecular FormulaC19H23N3O3
ClassOther
CategoryNootropics

Mechanism of Action

Coluracetam works primarily through potent and selective enhancement of high-affinity choline uptake (HACU) at cholinergic synapses, increasing the rate of acetylcholine synthesis. Unlike other HACU enhancers, its effects persist long after the drug has been cleared, suggesting lasting modification of the choline uptake system. It also showed activity in BrainCells Inc. Phase IIa trials for major depressive disorder with comorbid anxiety.

Dosing Research

Typical dose: 20-80 mg/day sublingually, divided into 2-3 doses. Most common: 20-35 mg sublingually twice daily. Sublingual preferred due to poor oral bioavailability. Half-life approximately 2-3 hours but effects on HACU are longer-lasting. Very limited human dosing data — start at the low end.

Side Effects & Risks

Very limited safety data. Reported: headache, fatigue, nausea. The visual enhancement effect (HD vision) reported by users is not well characterized in literature. No known serious adverse effects in short-term use. Long-term safety completely unknown. Expensive and difficult to source reliably.

Research Studies

Disclaimer

CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

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